APOE and atherosclerosis: Furthermore, the authors also showed that treatment with recombinant mouse IL-22 (rIL-22) markedly aggravates atherosclerosis development in apoE−/− mice fed a high-fat diet (HFD), whereas blocking circulating IL-22 with a neutralizer of IL-22 (IL-22 mAb) substantially reduces the atherosclerotic lesion area (Shi et al. 2020a).