Moreover, after treatment with recombinant mouse IL-22 in mice injected with angiotensin II, the interaction of IL-22 with IL-10R2 and IL-22R1 can activate the STAT3 signaling pathway, aggravating angiotensin II-induced inflammatory responses, endothelial dysfunction, and hypertension (Ye et al. 2017). This evidence concerns the gene IL22 and hypertensive disorder.