CD4 and HIV-1 infection: Despite the benefits of initiating ART at the earliest time possible following HIV-1 infection, other study findings from RV254/SEARCH 010 show that suboptimal CD4 T cell recovery still occurs in a small subset of individuals[23], early ART treatment during AHI only partially mitigates systemic immune inflammation[37], and rapid HIV RNA rebound occurs after ART interruption in individuals durably suppressed at the earliest stages of AHI[17].