CD4 and HIV-1 infection: To define cell-type specific genome-wide DNA methylation changes that relate to AHI, we first compared the methylomes of fluorescence-activated cell sorted monocytes and CD4+ T lymphocytes from 22 male Thai individuals living with acute HIV-1 infection in the RV254/SEARCH010 cohort (Fiebig stages I to V; median days since estimated exposure was 17.5 days) who were ART naive and 8 demographically matched HIV-1 uninfected Thai participants.