On the other hand, rat chromosome 2q14 (which harbors Gpbp1, Map3k1 and Il6st) coincides with Mamtr3 (also known as Mcs1b or Mcs10), another mammary-cancer susceptibility QTL for which the COP allele confers resistance to chemically induced mammary carcinogenesis [37]. The gene discussed is IL6ST; the disease is breast cancer.