DDX41 and myelodysplastic syndrome: This is interesting given a male bias of 1.8:1 for sporadic adult MDS (Greenberg et al., 2012; Stauder et al., 2018) and ~6:1 for germline DDX41‐driven MDS (Lewinsohn et al., 2016; Polprasert et al., 2015; Quesada et al., 2019; Sébert et al., 2019), and likely reflects the earlier onset of G2DS MDS associated with mechanistic specificities of disease pathobiology between different drivers of malignancy.