RUNX1 and acute myeloid leukemia: To date, no single underlying common phenotype has been described in the majority of G2DS carriers, in contrast to platelet function disorder or thrombocytopenia in Familial platelet disorder with predisposition to acute myeloid leukemia (FPD/AML, MONDO:0011071) caused by germline pathogenic variants in the RUNX1 gene.