We observed multiple cancer-related genes on broad-amplified chromosomes, e.g., chromosomes 5 and 14 (data not shown), despite only some cancer-related genes on these two chromosomes having focal CNVs, such as Gata4, Cdk6, and Cdk8. These co-occurring amplified cancer-related genes might act as drivers during cancer transformation [72]. The gene discussed is CDK8; the disease is cancer.