PRKN and cancer: SV breakpoints were also identified in seven other orthologs of human CFS genes: Immp2l, Negr1, Naaladl2, Ccser1, Prkn, Lsamp, and Gpc6. Seven of eight mice exhibited at least one SV in the human CFS gene ortholog; similar to human cancers, deletion and duplication were the dominant alterations in these genes [53].