HIF‐1 is an important mediator in inducing aerobic glycolysis in tumor cells,19 HIF‐1 expression is increased under hypoxia and activates adaptive transcriptional responses through related signaling pathways, which involves the upregulation of survival factors including angiogenic factors, regulating energy metabolism within tumor cells to adapt the tumor to a hypoxic TME and promote tumor cell metastasis and invasion.20, 21, 22. Here, HIF1A is linked to neoplasm.