Aerobic exercise decreases circulating levels of insulin, IGF1, and leptin, which is accompanied by altered metabolic signaling in tumor cells, as shown by increased AMPK activation and decreased levels of activated PI3K, Akt, and mTOR,73, 74 inhibits aerobic glycolysis in cancer cells and induces tumor cell apoptosis (Figure 2). Here, AKT1 is linked to neoplasm.