CD274 and neoplasm: Carey et al.44found that the majority of PD‐L1+ cells in the TME of CHL are tumor‐associated macrophages (TAMs). These PD‐L1+ TAMs regionally colocalize with HRS cells, suggesting that the elevated expression level of PD‐L1 on TAMs is in response to cytokine production, particularly IFN‐γ, by HRS cells.