Using these zebrafish Plin reporter lines in the context of diets (Stoletov et al., 2009; Turola et al., 2015; Sapp et al., 2014) and established zebrafish mutations and disease models (Hölttä-Vuori et al., 2013; Maddison et al., 2015; Liu et al., 2015; Liu et al., 2018; O’Hare et al., 2014) may provide mechanistic insights that connect PLIN cell biology to metabolic and cardiovascular diseases. This evidence concerns the gene PLIN1 and cardiovascular disorder.