In general, the risk score calculated from the risk model constructed by CELSR3, KLRB1, CENPA, CDCA8, PKIB, ADAMTS5, FTCD, CDX2, SFN, MYT1L and ZP3 could predict the prognosis of patients with HCC, with CENPA and CDCA8 as the two most significant factors. The gene discussed is ZP3; the disease is hepatocellular carcinoma.