The aim of this work is to test several new biomarkers such as BNP, plasma cardiotrophin (CT-1), human activin A (ACV-A), human transforming growth factors β1 (TGF-β1), human insulin-like growth factor binding protein-7 (IGFBP-7) in the early detection of systolic and diastolic dysfunction in the context of diabetes mellitus. This evidence concerns the gene NPPB and diabetes mellitus.