As for insulin action, Fluckey et al. found that unlike older healthy individuals, older individuals with T2D and young control participants each demonstrated increased insulin clearance as evidenced by a reduced total insulin response (area under curve; AUC) with no change in C-peptide response (an indirect index of insulin secretion) during OGTT 18 h after resistance training [59]. Here, INS is linked to type 2 diabetes mellitus.