For other clinical outcomes, no significant differences between groups, for either post-intervention values or changes, were observed for: most of the echocardiography parameters (Table 2.3); biomarkers such as NT-proBNP and hsCRP (Table 2.4); balance/mobility as measured by Timed up-and-go test (Table 2.5); quality of life (Table 2.6), or status of depression/anxiety (Table 2.7). The gene discussed is NPPB; the disease is major depressive disorder.