Similarly, in the presence of the three clinical comorbidities (obesity, diabetes, and oxygen saturation ≤ 93% or >50% lung involvement on CT), the probability of progression is 1% with lower IL-10 and IL-12 (p70) levels, but 97.5% with elevated levels of these biomarkers. Here, IL10 is linked to obesity due to melanocortin 4 receptor deficiency.