For the predictability of the functional severity of coronary stenosis of target vessel, the positive Youden index of the combined hs-CRP increased in model 4 (AUC: 0.881; C-index: 0.897; Youden index: 0.672; sensitivity: 89.6%; specificity: 73.1%; P < 0.001) (Figure 6). The gene discussed is CRP; the disease is coronary stenosis.