Interestingly, an effect on DNA repair through homologous recombination has also been appreciated (Vrouwe et al., 2007) and, very recently, alterations in the response to DNA damage were also reported in two lymphoblastoid cell lines derived from CdLS patients with heterozygous NIPBL mutations (Olley et al., 2021). This evidence concerns the gene NIPBL and Cornelia de Lange syndrome.