The expression of several genes potentially associated with the phenotypical traits typically observed in CdLS is affected in mouse and human models with NIPBL haploinsufficiency (Kawauchi et al., 2009; Liu et al., 2009; Remeseiro et al., 2013; Muto et al., 2014; Boudaoud et al., 2017; Mills et al., 2018; Luna-Peláez et al., 2019). Here, NIPBL is linked to Cornelia de Lange syndrome.