The TME is a complex ecosystem consisting of tumor cells, endogenous and tumor-induced stromal cells, vasculature (including vascular endothelia, pericytes, and perivascular cells), nerves and other sensory structures, and various organ/tissue-resident and recruited immune cell types as well as non-cellular components of the extracellular matrix such as collagen, fibronectins, and proteoglycans (Li et al., 2021; Rameshbabu et al., 2021; Vitale et al., 2021). This evidence concerns the gene FN1 and neoplasm.