This model could be applied to the case of patient VII: on one hand, the fact that the CDH13 variant was inherited from the healthy mother excludes a fully-penetrant effect in causing multiple melanomas, but on the other hand, it may be have played a role in the phenotype of the patient, possibly as the result of the co-existence with the PTEN variant, as CDH13 has previously been demonstrated to be implied in melanomagenesis (43–45). Here, PTEN is linked to melanoma.