In the attempt to identify additional genetic variants that could explain the multiple melanoma phenotype, WES was performed: first, an in silico panel of genes involved in predisposition to melanoma (CDKN2A, CDK4, BAP1, POT1, MITF, MC1R, TERT, XRCC3) was analyzed, with no pathogenic variants were found. The gene discussed is MC1R; the disease is melanoma.