In the attempt to identify additional genetic variants that could explain the multiple melanoma phenotype, WES was performed: first, an in silico panel of genes involved in predisposition to melanoma (CDKN2A, CDK4, BAP1, POT1, MITF, MC1R, TERT, XRCC3) was analyzed, with no pathogenic variants were found. This evidence concerns the gene CDKN2A and melanoma.