The follicular thyroid carcinoma of patient VII is the only exception: in the DNA extracted from the tumor, in fact, LOH clearly emerges, suggesting that the wild-type allele is at least partially deleted; consistently, the IHC analyses demonstrates absent expression of the PTEN protein associated with overexpression of phosphorylated-AKT. The gene discussed is AKT1; the disease is thyroid gland follicular carcinoma.