TRIM21 and hepatocellular carcinoma: Prognostic biomarkers in HCC have been identified: the overexpressions of XRCC5, IRF3, TRIM21, STAT6, DDX41, TBK1, XRCC6, TREX1, PRKDC, and STING are significantly related to the clinical stage and pathological grades of HCC (Qi et al., 2020).