Prognostic biomarkers in HCC have been identified: the overexpressions of XRCC5, IRF3, TRIM21, STAT6, DDX41, TBK1, XRCC6, TREX1, PRKDC, and STING are significantly related to the clinical stage and pathological grades of HCC (Qi et al., 2020). The gene discussed is PRKDC; the disease is hepatocellular carcinoma.