In contrast, transplanted CXCR4-positive expanded endothelial progenitor cells (EPCs), induced by CXCL12 into the rat liver portal tracts, fibrous septa and hepatic sinusoids, effectively promote the remodeling of damaged tissues of liver fibrosis and suppress liver fibrogenesis (Nakamura et al., 2012). The gene discussed is CXCL12; the disease is Hepatic fibrosis.