Using yeast two-hybrid screening with SARS-CoV-2 ORF3a as a bait, we captured a novel protein-protein interaction with UVRAG, a key autophagy regulator that activates PI3KC3 complex to promote autophagosome maturation and suppresses the proliferation of human colon cancer cells (Liang et al., 2006, 2008b). The gene discussed is UVRAG; the disease is colonic neoplasm.