HMGCS1 and posterior cortical atrophy: As expected, the key enzymes for cholesterol synthesis, 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGCR, the first-rate limiting enzyme) and 3-hydroxy-3-methyl-glutaryl-coenzyme A synthetase (HMGCS) are regulated by androgens and upregulated in PCa, especially in CRPC and contribute to CR [reviewed in (12)].