Using the same Hi-MYC mouse model, Blando and coworkers also showed that HFD-induced obesity enhances, whereas 30% caloric restriction reduces growth factor (AKT/mTORC1 and STAT3) and inflammatory (NFκB and cytokines) signaling and PCa progression (159). The gene discussed is MYC; the disease is obesity due to melanocortin 4 receptor deficiency.