Consistently, enzymes or transcriptional factors (TFs) involved in de novo FA synthesis such as the TF sterol regulatory element-binding proteins (SREBPs), ATP citrate lyase (ACLY), Acetyl-CoA carboxylase (ACC), and FASN are overexpressed in primary PCa and especially in mCRPC. The gene discussed is FASN; the disease is posterior cortical atrophy.