AKT1 and posterior cortical atrophy: Lipin-1 KD decreased both PCa cell proliferation and migration through RhoA activation, increased PA levels, and induced autophagy through the inhibition of PI3K/AKT/mTORC1 pathway., Lipin-1 depletion with propranolol sensitized cancer cells to rapamycin, suggesting new combination therapies (129, 130).