Herein, we integratedly analyzed miRNA and gene expression alterations in bone marrow (BM) Lin-Sca1+c-Kit+ cells (LSKs) of a tet-off inducible CML mouse model, Scl/tTA-BCR/ABL (BA). The gene discussed is ABL1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.