Moreover, insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) is reported to be oncogene, which is highly related to ESCC (10), and furthermore the abnormal expression of thymidine kinase 1 (TK1) is regarded as an important clinical characteristic in patients with ESCC (11). The gene discussed is IGF2BP2; the disease is esophageal squamous cell carcinoma.