Moreover, insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) is reported to be oncogene, which is highly related to ESCC (10), and furthermore the abnormal expression of thymidine kinase 1 (TK1) is regarded as an important clinical characteristic in patients with ESCC (11). This evidence concerns the gene TK1 and esophageal squamous cell carcinoma.