Many genetic variants found by genome-wide association studies (GWAS) increased the possibility of type 2 diabetes (Flannick & Florez, 2016), such as sex-determining region Y-related (SRY) high-mobility group box 4 (SOX4), which was discovered as a diabetes susceptibility gene and a new-called master regulator of EMT (Ragvin et al., 2010). The gene discussed is SOX4; the disease is diabetes mellitus.