In addition, while considering the isolated influence of GCs on bone biomarkers, these drugs decrease the expression of osteocalcin and procollagen I N-terminal propeptide,37,38 both important regulators of osteoblast differentiation.39 Systemic GCs are also related to damages to hierarchical bone structure, such as glucocorticoid-induced osteoporosis.33,40 This influence is widely speculated and seems to target bone through many paths. This evidence concerns the gene BGLAP and osteoporosis.