Biallelic null variants in TMC6 (MIM: 605828) and TMC8 (MIM: 605829) encoding EVER1 and EVER2 account for 50–60% of typical EV cases worldwide (Ramoz et al., 2002; Imahorn et al., 2017). The gene discussed is TMC6; the disease is epidermodysplasia verruciformis.