Moreover, PVT1 recruits the enhancer of Zeste homolog 2 (EZH2) to facilitate the recruitment of H3K27me3 to the FOXA1 promoter area, thus downregulating FOXA1 expression to promote apoptosis and podocyte damage in DN (Liu D. W. et al., 2019). This evidence concerns the gene PVT1 and liver dysplastic nodule.