Interestingly, several studies have shown that ICAM-1 gene polymorphisms were associated with susceptibility to breast cancer (Kammerer et al., 2004), gastric cancer (Tian et al., 2012), non-small cell lung cancer (Thanopoulou et al., 2012), hepatocellular carcinoma (Chen et al., 2016b), prostate cancer (Chen et al., 2006), melanoma (Natali et al., 1990), and ovarian cancer (Gardner et al., 1995), suggesting that the SNPs of the ICAM-1 gene may be common genetic factors that affect individual cancer susceptibility. This evidence concerns the gene ICAM1 and melanoma.