CRP and early-onset autosomal dominant Alzheimer disease: C-reactive protein (CRP) is a major acute-phase reactant and a sensitive biomarker of chronic low-grade inflammation (2) that has been viewed as a risk factor for cardiovascular diseases (3), cancers (2), type 2 diabetes (4), Alzheimer’s disease (AD) (5), schizophrenia (6), and autoimmune diseases (7), etc. Georgios et al.