Furthermore, the genetically determined CRP in the UK Biobank was negatively associated with hyperlipidemia, disorders of lipid metabolism, altered mental status, electrolyte imbalance, anemia of chronic disease, coronary atherosclerosis, ischemic heart disease, cerebrovascular disease, and cardiac pacemaker/device in situ, but positively associated with rheumatoid arthritis. This evidence concerns the gene CRP and metabolic process.