CD4 and breast cancer: We next evaluated the differentiation profile of CD4+ and CD8+ T cells from peripheral blood of BC patients and HDs using the combination of CCR7 and CD45RA markers to define: effector memory [CCR7−CD45RA−, (EM)], effector memory expressing CD45RA [CCR7−CD45RA+, (EMRA)], central memory [CCR7+ CD45RA−, (CM)], and naïve [CCR7+CD45RA+, (N)].