IL18R1 and periodontitis: It was demonstrated that the expression levels of inflammatory and epigenetic markers were elevated, which included interleukin-18 receptor 1 (IL-18R1, inflammatory marker), DNA methyltransferases 3b (DNMT3b, de novo methylation marker), and B and T lymphocyte attenuator (BTLA) in the gut and serum of mice with experimental periodontitis (126).