Although the costs are still high, the vast majority of cases can be solved by traditional Sanger sequencing of the relatively small HBA1, HBA2, and HBB genes, while NGS analysis cannot be sufficient to diagnose the hemoglobinopathies without using traditional methods involving hematology and Hb-typing to establish a proper genotype-phenotype correlation. This evidence concerns the gene GSTM1 and hemoglobinopathy.