As the results, the liver index, the spleen index (Figure 1A, p-value < 0.01, respectively), the liver levels of PDGF, TGF-β1, TIMP-1 and α-SMA (Figure 1C, p-value < 0.01, respectively), and the plasma level of LPS (Figure 1B, p-value < 0.01) were significantly increased in the HF group compared with the CON group. This evidence concerns the gene TIMP1 and hydrops fetalis.