After 8 weeks of intervention, YCWLP could significantly reduce the serum aspartate transaminase (AST), alanine transaminase (ALT), hyaluronidase (HA), laminin (LN), type IV collagen (CIV) and N-terminal propeptide of procollagen type III (PIIINP) of HF rats. This evidence concerns the gene GPT and hydrops fetalis.