APELA and cardiovascular disorder: In particular, similar to Ape13, Elabela which binds to APJ and activates the β-arrestin-2 and Gαi signaling pathways exerts protective effects against various cardiovascular diseases and related complications (Coquerel et al., 2018; Kuba et al., 2019; Liu et al., 2019; Chen et al., 2020a; Liu et al., 2020; Ma et al., 2020; Xu, 2020).