MAPT and cerebrovascular disorder: Although we did not find a significant association between depressive symptomatology and MRI markers of cerebrovascular disease, we cannot exclude that depressive symptomatology in our cohort could be an early symptom of other brain pathologies previously reported in SCD, such as amyloid-beta or tau pathologies (Amariglio et al., 2012; Perrotin et al., 2012; Buckley et al., 2017).