CIC and pachyonychia congenita: Cic, an evolutionarily conserved transcription factor from Caenorhabditis elegans to humans (Jimenez et al., 2000; Fores et al., 2017), is substantially downregulated in prostatic carcinoma (PC) (Choi et al., 2015), hepatocellular carcinoma (HCC) (Kim et al., 2018) and colorectal cancer (CRC) (Lee et al., 2020), suggesting that Cic may likely act as a tumor suppressor in cancer.