Nav1.8 was shown to be involved in diseases of the peripheral nervous system, such as chronic pain disorders (Faber et al., 2012; Huang et al., 2013b; Han et al., 2014; Kist et al., 2016), and arrhythmias (Bezzina et al., 2013). The gene discussed is SCN10A; the disease is cardiac arrhythmia.