LPAR1 and schizophrenia: Roberts et al. (2005) reported that Lpar1 mutation produces a number of changes in neurotransmitters, including 5-hydroxytryptamine (5-HT), tyrosine, aspartate, glutamate and γ-aminobutyric acid (GABA), that have been associated with a schizophrenia-like pathology in mice model. They found that a significant decrease of 5-HT and GABA, while a significant increase of tyrosine, aspartate and glutamate was observed in Lpar1 (–/–) mice compared with Lpar1 (+/+) mice (Roberts et al., 2005).