BRCA1 and breast cancer: As expected, some of the statistically significant associations that meet or exceed this threshold cover gene–disease relationships that are already tested in existing population screening programs: BRCA1 and BRCA2 with breast cancer (BRCA1p = 8.77×10-28, OR = 14.2; BRCA2p = 3.96×10-45, OR = 8.5), and LDLR with coronary atherosclerosis (p  = 1.46×10-12, OR = 17.5).