PKD2 and chronic kidney disease: Despite the similar effect sizes between LoF variants in PKD1 and PKD2, LoF variants in PKD2 occurred in only 0.02% and 0.01% of the UKB and HNP populations, respectively, compared to 0.03% and 0.06% for PKD1. With the HNP study continuing to enroll more participants, we will likely see additional individuals with a PKD2 variant and CKD, which would likely revise this screening recommendation to include both PKD1 and PKD2 for CKD.