GCK and cystic kidney disease: Additionally, we observed several statistically significant associations that have just as strong or stronger PPVs than these conditions, including LoF variants in HBB with hemoglobinopathies (p  = 1.91×10-129, OR = 197.2), LoF variants in PKD1 and with cystic kidney disease (p = 4.54×10-48, OR = 78.5), coding variants in GCK with diabetes mellitus (p = 1.46×10-33, OR = 11.3), and coding variants in MIP with cataracts (p = 1.56×10-10, OR = 4.6) (Table 2 and Fig. 1).