Furthermore, IFNγ downregulates the expression of SLC3A2 and SLC7A11, two subunits of the glutamate–cystine antiporter system xc−, impairs the uptake of cystine by tumor cells, and subsequently promotes tumor cell lipid peroxidation and ferroptosis [82, 83] (Fig. 5). This evidence concerns the gene SLC7A11 and neoplasm.