In addition to the well-known immunosuppressive networks, including CD4+Foxp3+ Tregs, myeloid-derived suppressor cells (MDSCs), and immune inhibitory macrophages [5], recent studies have demonstrated novel mechanisms affecting CD8+ T-cell function, including altering IFNγ expression in the colon cancer microenvironment. This evidence concerns the gene CD8A and malignant colon neoplasm.