Given that IFNGR1 palmitoylation is essential for its interaction with AP3D1 and subsequent IFNGR1 lysosomal sorting and degradation in colon cancer, suppression of IFNGR1 palmitoylation can restore cancer IFNγ signaling integrity and sensitize colorectal cancer cells to immunotherapy [69]. Here, IFNG is linked to malignant colon neoplasm.