For example, tumor cells highly express the methionine transporter SLC43A2, which can compete for methionine metabolism in CD8+ T cells, leading to decreased activation of STAT5 in CD8+ T cells and subsequent impairment of CD8+ T-cell IFNγ production in tumor-bearing mice and patients with colorectal cancer [21]. The gene discussed is SLC43A2; the disease is neoplasm.