The results predicted from four transgenic AD mouse models (5xFAD, APP-Tg, PS1-Tg, PS2-Tg) matched well with the external hold-out data of APPKM670/671NL-KI mice (Supplementary Figure 5b), indicating 79.2% of core nodes and 59.8% of core edges were precisely selected (Supplementary Figure 5b). Here, APP is linked to Alzheimer disease.