HMGB1 and early-onset autosomal dominant Alzheimer disease: We have already generated “human monoclonal antibody against human di-sulfate HMGB1 (hereafter described as an anti-HMGB1 antibody)” as described previously (Tanaka, H. et al. HMGB1 signaling phosphorylates Ku70 and impairs DNA damage repair in Alzheimer’s disease pathology.