We have already generated “human monoclonal antibody against human di-sulfate HMGB1 (hereafter described as an anti-HMGB1 antibody)” as described previously (Tanaka, H. et al. HMGB1 signaling phosphorylates Ku70 and impairs DNA damage repair in Alzheimer’s disease pathology. This evidence concerns the gene XRCC6 and Alzheimer disease.