Moreover, we confirmed a therapeutic effect of a human anti-HMGB1 human antibody, which interrupts the predicted AD-FTLD common pathway by HMGB1-induced signals (Tanaka, H. et al. HMGB1 signaling phosphorylates Ku70 and impairs DNA damage repair in Alzheimer’s disease pathology. This evidence concerns the gene HMGB1 and Alzheimer disease.