Clinical signs were also significantly exacerbated in CCR2-deficient mice as determined by the rotarod test (p < 0.05; 12 weeks to 17 weeks; Fig. 3b), grip strength (p < 0.05; 13 weeks to 15 weeks; Fig. 3c), and ALS-TDI scores (area under the curve from 7 to 19 weeks of age: p = 0.031; Fig. 3d, e) compared with CCR2-positive SOD1G93A littermates. This evidence concerns the gene CCR2 and amyotrophic lateral sclerosis.