Compared with that of mice in the blank group, tumor growth (Fig. 7c, d, Supplementary Fig. 4b) and weight (Fig. 7e, Supplementary Fig. 4c) were enhanced in the mice of the si-NC + OE-DDIT4, OE-KDM4A + PBS or OE-KDM4A + DMSO groups (p < 0.05), and this effect was neutralized by KDM4A silencing or everolimus treatment (p < 0.05). The gene discussed is KDM4A; the disease is neoplasm.