Mutations in well-known cancer genes located on chromosome 1p, such as NRAS (1p13.2), GADD45A (1p31.2–31.1), CDKN2C (1p32.2), RAD45(1p32) and EPB41 (1p36.2–p34), have so far only sporadically been detected26,28,34,35. The gene discussed is EPB41; the disease is cancer.