We found that 202 hyper-methylated regions were enriched in 5 pathways from the REACTOME and KEGG database including pathways regulating activation of HOX genes (2 pathways), the transcriptional regulation by TFAP2, the pluripotency of stem cells and the maturity of onset diabetes of the young (Fig. 4B). The gene discussed is TFAP2A; the disease is diabetes mellitus.