In addition, we further identified nine significant genes in PUBB (ADAMTS7, APOE, LPA, SH2B3, HNF1A, CELSR2, MYBPHL, ANGPTL4, EHBP1L1) that have been previously reported to be associated CAD by GBA (Table 1)6,23,24. Here, APOE is linked to coronary artery disorder.