In addition, we further identified nine significant genes in PUBB (ADAMTS7, APOE, LPA, SH2B3, HNF1A, CELSR2, MYBPHL, ANGPTL4, EHBP1L1) that have been previously reported to be associated CAD by GBA (Table 1)6,23,24. The gene discussed is ANGPTL4; the disease is coronary artery disorder.