Analysis of the combined RNA-Seq and ChIP-Seq data showed that the transcription of several of the differentially expressed genes with roles in TM, IOP, and glaucoma, were directly regulated by GLIS1 and included MYOC, LTBP2, CHI3L1, HMGA1, CYP1B1, and LOXL1-4 (Supplementary Table 2). The gene discussed is GLIS1; the disease is glaucoma.