In addition, we identified several transcriptional targets of GLIS1 in TM cells that previously have been implicated in TM-related functions, IOP homeostasis, and ocular hypertension/glaucoma, including MYOC, ADAMTS10, LTBP2, LOXL1, TGFBR3, CYP1B1, and EFEMP15,28,43,44. Here, CYP1B1 is linked to ocular hypertension.