Analysis of the combined RNA-Seq and ChIP-Seq data showed that the transcription of several of the differentially expressed genes with roles in TM, IOP, and glaucoma, were directly regulated by GLIS1 and included MYOC, LTBP2, CHI3L1, HMGA1, CYP1B1, and LOXL1-4 (Supplementary Table 2). This evidence concerns the gene CHI3L1 and glaucoma.