SREBF1 and neoplasm: As shown in Fig. 6A, knockout of TLR4 in the tumor tissues abolished the HFD-enhanced expressions of acetyl-CoA carboxylase (ACC), fatty acid synthase (FASN), carnitine palmitoyltransferase-1 (CPT-1), medium-chain acyl-CoA dehydrogenase (MCAD), glucose transporter GLUT1, and also sterol regulatory element-binding transcription factor-1 (SREBP-1c), the master transcription factor that regulates cellular lipogenesis and lipid homeostasis [29].