Nevertheless, the oncogenic role of TLR4 is challenged by a study showing that high-fat diet (HFD) promotes the polarization of adipose tissue macrophages from M2 to M1 phenotypes, and TLR4 promotes adipose tissue macrophage phagocytosis and secretion of Cxcl10 that recruits T cells and inhibits the peritoneal seeding of CRC cells [20]. The gene discussed is TLR4; the disease is colorectal carcinoma.