TLR4 and peripheral arterial disease: As shown in Supplementary Fig. S1B, C, inhibition of TLR4 activity in the tumor did not affect the relative percentages of M1 and M2 macrophages under different dietary interventions, it reduced the relative NK and cytotoxic T-cell populations in the tumor under HFD feeding, but not PAD feeding, when compared with the respective matched control diet.