TLR4 and colorectal carcinoma: More importantly, they were mainly involved in energy production (Supplementary Fig. S2C) and took part in triglyceride biosynthesis, glucose metabolism, fatty acid activation, fatty acid, triglyceride, and ketone synthesis (Supplementary Fig. S2D) in a cooperative manner, as illustrated in the STRING analysis (Fig. 6E), suggesting that the regulatory role of TLR4 on CRC metabolism under HFD conditions is not attributed to a single metabolic enzyme but a collaborative work of the enzymes.