Cluster C5 contained 9 cholesterogenic genes, including ACAT2, CYP51A, DHCR24, DHCR7, HMGCR, HMGCS1, IDI1, MSMO1, and SQLE, and Cluster C6 contained 12 glycolytic genes, including GNPDA1, NUP188, NUP205, NUP214, NUP62, NUP85, POM121, POM121C, PPP2R1A, PPP2R5D, PRKACA, and RAE1. Multiple genes have been digested in melanoma research and found to interfere with melanoma proliferation [35–43]. The gene discussed is HMGCR; the disease is melanoma.