BIN1 and Mental deterioration: Besides biomarkers of Aβ and tau accumulation, there are numerous other factors that have been associated with cognitive decline and conversion risk, including lifestyle and reserve-related factors (e.g., physical activity, education) [40], genetic risk (e.g. APOE4, BIN1, BDNF) [41–43], neuroimmune markers (e.g., sTREM2) [44], and neurodegeneration [45] as for instance measured with MRI, FDG-PET, or neurofilament light.